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Article

Voltage-gated sodium channel scn8a is required for innervation and regeneration of amputated adult zebrafish fins.

Proceedings of the National Academy of Sciences of the United States of America - 12 Jul 2022

Osorio-Méndez Daniel, Miller Andrew, Begeman Ian J, Kurth Andrew, Hagle Ryan, Rolph Daniela, Dickson Amy L, Chen Chen-Hui, Halloran Mary, Poss Kenneth D, Kang Junsu

Abstract excerpt

Teleost fishes and urodele amphibians can regenerate amputated appendages, whereas this ability is restricted to digit tips in adult mammals. One key component of appendage regeneration is reinnervation of the wound area. However, how innervation is regulated in injured appendages of adult vertebrates has seen limited research attention. From a forward genetics screen for temperature-sensitive defects in...

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PMID: 35867745
DOI: 10.1073/pnas.2200342119
PMCID: PMC9282381

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