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Article

Embryonic spinocerebellar ataxia type 37-associated AUUUC repeat RNA causes neurodevelopmental defects.

Disease models & mechanisms - 1 Apr 2026

Castro Ana F, Figueiredo Ana S, Loureiro Joana R, Azevedo Maria M, Sampaio Paula, Valentim Ana M, Bessa José, Silveira Isabel

Abstract excerpt

Onset of many neurodegenerative and neuromuscular diseases usually starts in adulthood; however, recent advances point towards neurodevelopmental changes as drivers of late neurodegeneration. How early neuropathological features occur under these conditions remains unclear, but this knowledge would be critical for timely therapeutic intervention. Here, we provide evidence that neurodevelopmental axonal defects...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41854242
DOI: 10.1242/dmm.052636
PMCID: PMC13225218

Genes

DAB1
NOVA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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