Article
Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model.
Cellular and molecular gastroenterology and hepatology - 1 Jan 2022
Ceci Ludovica, Chen Lixian, Baiocchi Leonardo, Wu Nan, Kennedy Lindsey, Carpino Guido, Kyritsi Konstantina, Zhou Tianhao, Owen Travis, Kundu Debjyoti, Sybenga Amelia, Isidan Abdulkadir, Ekser Burcin, Franchitto Antonio, Onori Paolo, Gaudio Eugenio, Mancinelli Romina, Francis Heather, Alpini Gianfranco, Glaser Shannon
Abstract excerpt
BACKGROUND & AIMS: Primary sclerosing cholangitis (PSC) is characterized by biliary senescence and hepatic fibrosis. Melatonin exerts its effects by interacting with Melatonin receptor 1 and 2 (MT1/MT2) melatonin receptors. Short-term (1 wk) melatonin treatment reduces a ductular reaction and liver fibrosis in bile duct-ligated rats by down-regulation of MT1 and clock genes, and in multidrug resistance gene...
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