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Article

SARS-CoV-2 Spike- and Nucleoprotein-Specific Antibodies Induced After Vaccination or Infection Promote Classical Complement Activation

4 Jul 2022

Abstract excerpt

Antibodies specific for the spike glycoprotein (S) and nucleocapsid (N) SARS-CoV-2 proteins are typically present during severe COVID-19, and induced to S after vaccination. The binding of viral antigens by antibody can initiate the classical complement pathway. Since complement could play pathological or protective roles at distinct times during SARS-CoV-2 infection we determined levels of antibody-dependent...

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Identifiers

PMID: 35860286
DOI: 10.3389/fimmu.2022.838780

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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