Article

Anti-SARS-Cov-2 S-RBD IgG formed after BNT162b2 vaccination can bind C1q and activate complement

2022-04-26

Abstract excerpt

<h4>Introduction</h4> Activation of the classical complement pathway through C1q binding to immunoglobulins (Ig) contributes to pathogen neutralization, thus, the ability of Ig produced after vaccination to bind C1q could affect vaccine efficacy. In this study, we investigated C1q binding and subsequent complement activation by anti-spike (S) protein receptor-binding domain (RBD) specific antibodies produced foll...

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Literature Corpus work: ea3356c9-c1bb-5786-b6d5-317429dbd535
DOI: 10.1101/2022.04.24.489298

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