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Article

Metabolic transitions define spermatogonial stem cell maturation

20 Jul 2022

Abstract excerpt

STUDY QUESTION: Do spermatogonia, including spermatogonial stem cells (SSCs), undergo metabolic changes during prepubertal development? SUMMARY ANSWER: Here, we show that the metabolic phenotype of prepubertal human spermatogonia is distinct from that of adult spermatogonia and that SSC development is characterized by distinct metabolic transitions from oxidative phosphorylation (OXPHOS) to anaerobic metabolism....

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PMID: 35856882
DOI: 10.1093/humrep/deac157

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