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Impact of hyperglycemia on early embryo development and embryopathy: in vitro experiments using a mouse model

13 Oct 2007

Abstract excerpt

BACKGROUND: The aim of this study is to model the processes of early embryopathy seen in human pregnancy complicated by maternal hyperglycemia secondary to maternal diabetes using a mouse embryo culture system. METHODS: Female mice were superovulated and mated in pairs. Two-cell embryos were harvested from the oviducts and cultured in vitro in KSOM medium (synthetic oviductal medium enriched with potassium)...

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PMID: 17933753
DOI: 10.1093/humrep/dem318

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