Article
Applying fluorescent dye assays to discriminate Escherichia coli chlorhexidine resistance phenotypes from porin and mlaA deletions and efflux pumps.
Scientific reports - 15 Jul 2022
Gregorchuk Branden S J, Reimer Shelby L, Slipski Carmine J, Milner Kieran A, Hiebert Shannon L, Beniac Daniel R, Booth Timothy F, Zhanel George G, Bay Denice C
Abstract excerpt
Bacterial resistance to the antiseptic chlorhexidine (CHX), is a growing problem, recently shown to be caused by deleterious mutations to the phospholipid transport system component (mlaA) as well as efflux pump overexpression. Comparisons of CHX resistance mechanisms, such as porin deletions (ompCF), and over-expressed efflux pumps (acrB, qacE, aceI), are lacking and may be distinguishable using antiseptic rapid...
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