Article
Salt-inducible multidrug efflux pump protein in the moderately halophilic bacterium Chromohalobacter sp.
Applied and environmental microbiology - 1 Aug 2004
Tokunaga Hiroko, Mitsuo Kenjiro, Ichinose Sachiyo, Omori Akira, Ventosa Antonio, Nakae Taiji, Tokunaga Masao
Abstract excerpt
It has been known that halophilic bacteria often show natural resistance to antibiotics, dyes, and toxic metal ions, but the mechanism and regulation of this resistance have remained unexplained. We have addressed this question by identifying the gene responsible for multidrug resistance. A spontaneous ofloxacin-resistant mutant derived from the moderately halophilic bacterium Chromohalobacter sp. strain 160...
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