Evaluation of reduced susceptibility to quaternary ammonium compounds and bisbiguanides in clinical isolates and laboratory-generated mutants of Staphylococcus aureus.

doi:10.1128/AAC.00498-13

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Article

Evaluation of reduced susceptibility to quaternary ammonium compounds and bisbiguanides in clinical isolates and laboratory-generated mutants of Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Aug 2013

Furi Leonardo, Ciusa Maria Laura, Knight Daniel, Di Lorenzo Valeria, Tocci Nadia, Cirasola Daniela, Aragones Lluis, Coelho Joana Rosado, Freitas Ana Teresa, Marchi Emmanuela, Moce Laura, Visa Pilar, Northwood John Blackman, Viti Carlo, Borghi Elisa, Orefici Graziella, Morrissey Ian, Oggioni Marco Rinaldo

Abstract excerpt

The MICs and minimum bactericidal concentrations (MBCs) for the biocides benzalkonium chloride and chlorhexidine were determined against 1,602 clinical isolates of Staphylococcus aureus. Both compounds showed unimodal MIC and MBC distributions (2 and 4 or 8 mg/liter, respectively) with no apparent subpopulation with reduced susceptibility. To investigate further, all isolates were screened for qac genes, and 39...

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PMID: 23669380
DOI: 10.1128/AAC.00498-13
PMCID: PMC3719693

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