Article
The transfer of adaptive immunity to CMV during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donor.
Blood - 3 Dec 2009
Scheinberg Phillip, Melenhorst Jan J, Brenchley Jason M, Hill Brenna J, Hensel Nancy F, Chattopadhyay Pratip K, Roederer Mario, Picker Louis J, Price David A, Barrett A John, Douek Daniel C
Abstract excerpt
The successful reconstitution of adaptive immunity to human cytomegalovirus (CMV) in hematopoietic stem cell transplantation (HSCT) recipients is central to the reduction of viral reactivation-related morbidity and mortality. Here, we characterized the magnitude, specificity, phenotype, function, and clonotypic composition of CMV-specific T-cell responses in 18 donor-recipient pairs both before and after HSCT....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.