Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits.

doi:10.1038/ng.3888

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Article

Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits.

Nature genetics - 1 Nov 2017

Hammerschlag Anke R, Stringer Sven, de Leeuw Christiaan A, Sniekers Suzanne, Taskesen Erdogan, Watanabe Kyoko, Blanken Tessa F, Dekker Kim, Te Lindert Bart H W, Wassing Rick, Jonsdottir Ingileif, Thorleifsson Gudmar, Stefansson Hreinn, Gislason Thorarinn, Berger Klaus, Schormair Barbara, Wellmann Juergen, Winkelmann Juliane, Stefansson Kari, Oexle Konrad, Van Someren Eus J W, Posthuma Danielle

Abstract excerpt

Persistent insomnia is among the most frequent complaints in general practice. To identify genetic factors for insomnia complaints, we performed a genome-wide association study (GWAS) and a genome-wide gene-based association study (GWGAS) in 113,006 individuals. We identify three loci and seven genes associated with insomnia complaints, with the associations for one locus and five genes supported by joint...

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PMID: 28604731
DOI: 10.1038/ng.3888
PMCID: PMC5600256

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