Article
A powerful global test for spliceQTL effects.
Biometrical journal. Biometrische Zeitschrift - 1 Jan 2023
de Menezes Renee X, Rauschenberger Armin, 't Hoen Peter A C, Jonker Marianne A
Abstract excerpt
Statistical methods to test for effects of single nucleotide polymorphisms (SNPs) on exon inclusion exist but often rely on testing of associations between multiple exon-SNP pairs, with sometimes subsequent summarization of results at the gene level. Such approaches require heavy multiple testing corrections and detect mostly events with large effect sizes. We propose here a test to find spliceQTL (splicing...
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