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Article

Single mutations toggle the substrate selectivity of multifunctional Camptotheca secologanic acid synthases.

The Journal of biological chemistry - 1 Sept 2022

Miller Justin C, Schuler Mary A

Abstract excerpt

Terpene indole alkaloids (TIAs) are plant-derived specialized metabolites with widespread use in medicine. Species-specific pathways derive various TIAs from common intermediates, strictosidine or strictosidinic acid, produced by coupling tryptamine with secologanin or secologanic acid. The penultimate reaction in this pathway is catalyzed by either secologanin synthase (SLS) or secologanic acid synthase (SLAS)...

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PMID: 35809640
DOI: 10.1016/j.jbc.2022.102237
PMCID: PMC9424959

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