Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel heptasomy 21 associated with complete loss of heterozygosity and loss of function RUNX1 mutation in acute myeloid leukemia.

Cancer genetics - 1 Aug 2022

Yang Fei, Akkari Yassmine, Fan Guang, Olson Susan, Moore Stephen

Abstract excerpt

Chromosomal aberrations are among the most important prognostic parameters in AML, and conventional cytogenetic analysis remains essential for risk stratification. In this report, we describe an adult male patient with a high percentage of circulating blasts, pathologically confirmed as AML with maturation. Cytogenetic analysis of a bone marrow sample revealed heptasomy 21 and trisomy 13 within a complex...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Aberrations
Share to Core Binding Factor Alpha 2 Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Loss of Heterozygosity

Share to Mutation

Share to Trisomy

Source

Identifiers

PMID: 35802949
DOI: 10.1016/j.cancergen.2022.07.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel heptasomy 21 associated with complete loss of heterozygosity and loss of function RUNX1 mutation in acute myeloid leukemia.PMID 35802949Read ↗

Cytogenetic and Molecular Analysis of a "Double-Hit" RUNX1 Including a RUNX1 p.Trp279* and a Cryptic Novel t(6;21)(q25;q22)/RUNX1::ARID1B in Acute Myeloid Leukemia.Semantic proximity Read ↗

Molecular genetic characterization of acute myeloid leukemia with isolated trisomy of chromosomes 4, 11, and 21.Semantic proximity Read ↗

Myeloid malignancies with acquired trisomy 21 as the sole cytogenetic change are clinically highly variable and display a heterogeneous pattern of copy number alterations and mutations.Semantic proximity Read ↗

Cytogenetic analysis of acute myeloid leukemia with t(8;21) from a tertiary care center in India with correlation between clinicopathologic characteristics and molecular analysis.Semantic proximity Read ↗

Rare and novel RUNX1 fusions in myeloid neoplasms: A single-institute experience.Semantic proximity Read ↗

Adverse outcomes and high incidence of therapy-related neoplasms in patients with the t(16;21)/RUNX1::RUNX1T3 fusion.Semantic proximity Read ↗

Loss of genetic material is more common than gain in acute myeloid leukemia with complex aberrant karyotype: A detailed analysis of 125 cases using conventional chromosome analysis and fluorescence in situ hybridization including 24‐color FISHSemantic proximity Read ↗

Poor outcome in a pediatric patient with acute myeloid leukemia associated with a variant t(8;21) and trisomy 6.Semantic proximity Read ↗

Acute myeloid leukemia harboring t(8;21)(q22;q22): a heterogeneous disease with poor outcome in a subset of patients unrelated to secondary cytogenetic aberrationsSemantic proximity Read ↗

Acquired Isodisomy for chromosome 13 is common in AML, and associated with FLT3-itd mutationsSemantic proximity Read ↗

A novel t(X;21)(p11.4;q22.12) translocation adds to the role of BCOR and RUNX1 in myelodysplastic syndromes and acute myeloid leukemias.Semantic proximity Read ↗

ERG amplification is a secondary recurrent driver event in myeloid malignancy with complex karyotype and TP53 mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.