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Article

Tumor Cells Modulate Macrophage Phenotype in a Novel In Vitro Co-Culture Model of the NSCLC Tumor Microenvironment.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Oct 2022

Park Josiah Voth, Chandra Raghav, Cai Ling, Ganguly Debolina, Li Huiyu, Toombs Jason E, Girard Luc, Brekken Rolf A, Minna John D

Abstract excerpt

INTRODUCTION: Macrophage phenotype in the tumor microenvironment correlates with prognosis in NSCLC. Immunosuppressive macrophages promote tumor progression, whereas proinflammatory macrophages may drive an antitumor immune response. How individual NSCLCs affect macrophage phenotype is a major knowledge gap. METHODS: To systematically study the impact of lung cancer cells on macrophage phenotypes, we developed an...

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Source

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Identifiers

PMID: 35798240
DOI: 10.1016/j.jtho.2022.06.011
PMCID: PMC9529910

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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