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Article

Enhanced stability of M1 protein mediated by a phospho-resistant mutation promotes the replication of prevailing avian influenza virus in mammals.

PLoS pathogens - 1 Jul 2022

Wang Chenxi, Qu Runkang, Zong Yanan, Qin Chao, Liu Litao, Gao Xiaoyi, Sun Honglei, Sun Yipeng, Chang Kin-Chow, Zhang Rui, Liu Jinhua, Pu Juan

Abstract excerpt

Avian influenza virus (AIV) can evolve multiple strategies to combat host antiviral defenses and establish efficient infectivity in mammals, including humans. H9N2 AIV and its reassortants (such as H5N6 and H7N9 viruses) pose an increasing threat to human health; however, the mechanisms involved in their increased virulence remain poorly understood. We previously reported that the M1 mutation T37A has become...

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PMID: 35793327
DOI: 10.1371/journal.ppat.1010645
PMCID: PMC9258882

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