Article
Characterization of the Immunological Status of Hypermutated Solid Tumors in the Cancer Genome Analysis Project HOPE.
Anticancer research - 1 Jul 2022
Akiyama Yasuto, Kondou Ryota, Iizuka Akira, Miyata Haruo, Maeda Chie, Kanematsu Akari, Ashizawa Tadashi, Nagashima Takeshi, Urakami Kenichi, Shimoda Yuji, Ohshima Keiichi, Shiomi Akio, Ohde Yasuhisa, Terashima Masanori, Uesaka Katsuhiko, Hirashima Yasuyuki, Kiyohara Yoshio, Katagiri Hirohisa, Sugino Takashi, Notsu Akifumi, Mori Keita, Takahashi Mitsuru, Kenmotsu Hirotsugu, Yamaguchi Ken
Abstract excerpt
BACKGROUND: Many reports demonstrate that a high tumor mutation burden (TMB-H) is closely associated with good prognosis of cancer. However, specific studies investigating the association of various TMB statuses with overall survival in patients with solid tumors are scarce. PATIENTS AND METHODS: In the present study, we investigated the association of TMB status with overall survival in 5,072 patients with...
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