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Identification of endoplasmic reticulum stress genes in human stroke based on bioinformatics and machine learning

26 Jun 2024

Abstract excerpt

After ischemic stroke (IS), secondary injury is intimately linked to endoplasmic reticulum (ER) stress and body-brain crosstalk. Nonetheless, the underlying mechanism systemic immune disorder mediated ER stress in human IS remains unknown. In this study, 32 candidate ER stress-related genes (ERSRGs) were identified by overlapping MSigDB ER stress pathway genes and DEGs. Three Key ERSRGs (ATF6, DDIT3 and ERP29)...

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PMID: 38942324
DOI: 10.1016/j.nbd.2024.106583

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