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Article

Lack of CCR3 leads to a skeletal phenotype only in male mice.

Biochemical and biophysical research communications - 10 Sept 2022

Rosendahl Sara, Sulniute Rima, Persson Julia, Forsberg Sebastian, Häggvik Rebecka, Drewsen Viktor, Koskinen Holm Cecilia, Kindstedt Elin, Lundberg Pernilla

Abstract excerpt

We recently showed that adult male mice that lacked the C-C-chemokine receptor 3 (CCR3) exhibited disturbed bone remodeling, which resulted in a cortical bone phenotype of thin femoral cortical bone. However, it remains unknown whether this phenotype would be present during bone modeling, or it affects female mice. Here, we analyzed juvenile and adolescent CCR3-deficient mice to determine when bone modeling was...

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Identifiers

PMID: 35780587
DOI: 10.1016/j.bbrc.2022.06.062

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