Article
De novo Mutations in Domestic Cat are Consistent with an Effect of Reproductive Longevity on Both the Rate and Spectrum of Mutations.
Molecular biology and evolution - 2 Jul 2022
Wang Richard J, Raveendran Muthuswamy, Harris R Alan, Murphy William J, Lyons Leslie A, Rogers Jeffrey, Hahn Matthew W
Abstract excerpt
The mutation rate is a fundamental evolutionary parameter with direct and appreciable effects on the health and function of individuals. Here, we examine this important parameter in the domestic cat, a beloved companion animal as well as a valuable biomedical model. We estimate a mutation rate of 0.86 × 10-8 per bp per generation for the domestic cat (at an average parental age of 3.8 years). We find evidence for...
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