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Article

Dynamic rewiring of biological activity across genotype and lineage revealed by context-dependent functional interactions.

Genome biology - 29 Jun 2022

Kim Eiru, Novak Lance C, Lin Chenchu, Colic Medina, Bertolet Lori L, Gheorghe Veronica, Bristow Christopher A, Hart Traver

Abstract excerpt

BACKGROUND: Coessentiality networks derived from CRISPR screens in cell lines provide a powerful framework for identifying functional modules in the cell and for inferring the roles of uncharacterized genes. However, these networks integrate signal across all underlying data and can mask strong interactions that occur in only a subset of the cell lines analyzed. RESULTS: Here, we decipher dynamic functional...

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Identifiers

PMID: 35768873
DOI: 10.1186/s13059-022-02712-z
PMCID: PMC9241233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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