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Report on the first SLFN11 monothematic workshop: from function to role as a biomarker in cancer

2 Oct 2017

Abstract excerpt

SLFN11 is a recently discovered protein with a putative DNA/RNA helicase function. First identified in association with the maturation of thymocytes, SLFN11 was later causally associated, by two independent groups, with the resistance to DNA damaging agents such as topoisomerase I and II inhibitors, platinum compounds, and other alkylators, making it an attractive molecule for biomarker development. Later, SLFN11...

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PMID: 28969705
DOI: 10.1186/s12967-017-1296-3

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