Article
Glomerular parietal epithelial cells of adult murine kidney undergo EMT to generate cells with traits of renal progenitors.
Journal of cellular and molecular medicine - 1 Feb 2011
Swetha G, Chandra Vikash, Phadnis Smruti, Bhonde Ramesh
Abstract excerpt
Glomerular parietal epithelial cells (GPECs) are known to revert to embryonic phenotype in response to renal injury. However, the mechanism of de-differentiation in GPECs and the underlying cellular processes are not fully understood. In the present study, we show that cultured GPECs of adult murine kidney undergo epithelial-mesenchymal transition (EMT) to generate cells, which express CD24, CD44 and CD29 surface...
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