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Article

RDscan: A New Method for Improving Germline and Somatic Variant Calling Based on Read Depth Distribution.

Journal of computational biology : a journal of computational molecular cell biology - 1 Sept 2022

Lee Sunho, Hong Seokchol, Woo Jonathan, Lee Jae-Hak, Kim Kyunghee, Kim Lucia, Park Kunsoo, Jung Jongsun

Abstract excerpt

Several tools have been developed for calling variants from next-generation sequencing (NGS) data. Although they are generally accurate and reliable, most of them have room for improvement, especially regarding calling variants in datasets with low read depth. In addition, the somatic variants predicted by several somatic variant callers tend to have very low concordance rates. In this study, we developed a new...

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PMID: 35749140
DOI: 10.1089/cmb.2021.0269

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