Article
Highly Sensitive Lineage Discrimination of SARS-CoV-2 Variants through Allele-Specific Probe PCR.
Journal of clinical microbiology - 20 Apr 2022
Ratcliff Jeremy, Al-Beidh Farah, Bibi Sagida, Bonsall David, Costa Clemens Sue Ann, Estcourt Lise, Evans Amy, Fish Matthew, Folegatti Pedro M, Gordon Anthony C, Jay Cecilia, Jennings Aislinn, Laing Emma, Lambe Teresa, MacIntyre-Cockett George, Menon David, Mouncey Paul R, Nguyen Dung, Pollard Andrew J, Ramasamy Maheshi N, Roberts David J, Rowan Kathryn M, Rynne Jennifer, Shankar-Hari Manu, Williams Sarah, Harvala Heli, Golubchik Tanya, Simmonds Peter
Abstract excerpt
Tools to detect SARS-CoV-2 variants of concern and track the ongoing evolution of the virus are necessary to support public health efforts and the design and evaluation of novel COVID-19 therapeutics and vaccines. Although next-generation sequencing (NGS) has been adopted as the gold standard method for discriminating SARS-CoV-2 lineages, alternative methods may be required when processing samples with low viral...
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