Article
Nucleocapsid (N) Gene Mutations of SARS-CoV-2 Can Affect Real-Time RT-PCR Diagnostic and Impact False-Negative Results.
Viruses - 10 Dec 2021
Lesbon Jéssika Cristina Chagas, Poleti Mirele Daiana, de Mattos Oliveira Elisângela Chicaroni, Patané José Salvatore Leister, Clemente Luan Gaspar, Viala Vincent Louis, Ribeiro Gabriela, Giovanetti Marta, de Alcantara Luiz Carlos Junior, Teixeira Olivia, Nonato Maria Cristina, de Lima Loyze Paola Oliveira, Martins Antonio Jorge, Dos Santos Barros Claudia Renata, Marqueze Elaine Cristina, de Souza Todão Bernardino Jardelina, Moretti Debora Botequio, Brassaloti Ricardo Augusto, de Lello Rocha Campos Cassano Raquel, Mariani Pilar Drummond Sampaio Correa, Slavov Svetoslav Nanev, Dos Santos Rafael Bezerra, Rodrigues Evandra Strazza, Santos Elaine Vieira, Borges Josiane Serrano, de La Roque Debora Glenda Lima, Kitajima Joao Paulo, Santos Bibiana, Assato Patricia Akemi, da Silva da Costa Felipe Allan, Banho Cecilia Artico, Sacchetto Livia, Moraes Marilia Mazzi, Palmieri Melissa, da Silva Fabiana Erica Vilanova, Grotto Rejane Maria Tommasini, Souza-Neto Jayme A, Nogueira Mauricio Lacerda, Coutinho Luiz Lehman, Calado Rodrigo Tocantins, Neto Raul Machado, Covas Dimas Tadeu, Kashima Simone, Elias Maria Carolina, Sampaio Sandra Coccuzzo, Fukumasu Heidge
Abstract excerpt
The current COVID-19 pandemic demands massive testing by Real-time RT-PCR (Reverse Transcription Polymerase Chain Reaction), which is considered the gold standard diagnostic test for the detection of the SARS-CoV-2 virus. However, the virus continues to evolve with mutations that lead to phenotypic alterations as higher transmissibility, pathogenicity or vaccine evasion. Another big issue are mutations in the...
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