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Article

Developmental exposure to real-life environmental chemical mixture programs a testicular dysgenesis syndrome-like phenotype in prepubertal lambs.

Environmental toxicology and pharmacology - 1 Aug 2022

Elcombe Chris S, Monteiro Ana, Elcombe Matthew R, Ghasemzadeh-Hasankolaei Mohammad, Sinclair Kevin D, Lea Richard, Padmanabhan Vasantha, Evans Neil P, Bellingham Michelle

Abstract excerpt

Current declines in male reproductive health may, in part, be driven by anthropogenic environmental chemical (EC) exposure. Using a biosolids treated pasture (BTP) sheep model, this study examined the effects of gestational exposure to a translationally relevant EC mixture. Testes of 8-week-old ram lambs from mothers exposed to BTP during pregnancy contained fewer germ cells and had a greater proportion of...

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Identifiers

PMID: 35738462
DOI: 10.1016/j.etap.2022.103913
PMCID: PMC9554787

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