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Article

Excess Testosterone Exposure Alters Hypothalamic-Pituitary-Testicular Axis Dynamics and Gene Expression in Sheep Fetuses.

Endocrinology - 1 Nov 2016

Roselli Charles E, Amodei Rebecka, Gribbin Kyle P, Corder Keely, Stormshak Fred, Estill Charles T

Abstract excerpt

Prenatal exposure to excess androgen may result in impaired adult fertility in a variety of mammalian species. However, little is known about what feedback mechanisms regulate gonadotropin secretion during early gestation and how they respond to excess T exposure. The objective of this study was to determine the effect of exogenous exposure to T on key genes that regulate gonadotropin and GnRH secretion in fetal...

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Identifiers

PMID: 27673555
DOI: 10.1210/en.2016-1411
PMCID: PMC5086533

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