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Article

Reduction of A-to-I RNA editing in the failing human heart regulates formation of circular RNAs

23 Jun 2022

Abstract excerpt

Alterations of RNA editing that affect the secondary structure of RNAs can cause human diseases. We therefore studied RNA editing in failing human hearts. Transcriptome sequencing showed that adenosine-to-inosine (A-to-I) RNA editing was responsible for 80% of the editing events in the myocardium. Failing human hearts were characterized by reduced RNA editing. This was primarily attributable to Alu elements in...

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PMID: 35737129
DOI: 10.1007/s00395-022-00940-9

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