Article
Single-Cell Metabolic Profiling of Macrophages Using 3D OrbiSIMS: Correlations with Phenotype.
Analytical chemistry - 5 Jul 2022
Suvannapruk Waraporn, Edney Max K, Kim Dong-Hyun, Scurr David J, Ghaemmaghami Amir M, Alexander Morgan R
Abstract excerpt
Macrophages are important immune cells that respond to environmental cues acquiring a range of activation statuses represented by pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes at each end of their spectrum. Characterizing the metabolic signature (metabolic profiling) of different macrophage subsets is a powerful tool to understand the response of the human immune system to different stimuli. Here,...
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