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Article

Alcohol consumption, blood DNA methylation and breast cancer: a Mendelian randomisation study.

European journal of epidemiology - 1 Jul 2022

Zhou Xuan, Yu Lili, Wang Lijuan, Xiao Jiarui, Sun Jing, Zhou Yajing, Xu Xiaolin, Xu Wanghong, Spiliopoulou Athina, Timofeeva Maria, Zhang Xiaomeng, He Yazhou, Yang Haomin, Campbell Harry, Zhang Ben, Zhu Yimin, Theodoratou Evropi, Li Xue

Abstract excerpt

Alcohol intake is thought to be a risk factor for breast cancer, but the causal relationship and carcinogenic mechanisms are not clear. We performed an up-to-date meta-analysis of prospective studies to assess observational association, and then conducted MR analysis to make causal inference based on the genetic predisposition to alcohol consumption ("drinks per week") and pathological drinking behaviours...

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Identifiers

PMID: 35708873
DOI: 10.1007/s10654-022-00886-1
PMCID: PMC9329409

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