Post-trauma behavioral phenotype predicts the degree of vulnerability to fear relapse after extinction in male rats.

doi:10.1016/j.cub.2022.05.050

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Article

Post-trauma behavioral phenotype predicts the degree of vulnerability to fear relapse after extinction in male rats.

Current biology : CB - 25 Jul 2022

Demars Fanny, Todorova Ralitsa, Makdah Gabriel, Forestier Antonin, Krebs Marie-Odile, Godsil Bill P, Jay Thérèse M, Wiener Sidney I, Pompili Marco N

Abstract excerpt

Current treatments for trauma-related disorders remain ineffective for many patients.1,2 Fear extinction deficiency is a prominent feature of these diseases,3 and many behavioral treatments rely on extinction training.4,5 However, in many patients, therapy is followed by a relapse of symptoms, and the underpinnings of such interindividual variations in vulnerability to relapse remain unknown.6-8 Here, we modeled...

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PMID: 35705096
DOI: 10.1016/j.cub.2022.05.050

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