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Article

Up-front cell-free DNA next generation sequencing improves target identification in UK first line advanced non-small cell lung cancer (NSCLC) patients.

European journal of cancer (Oxford, England : 1990) - 1 Aug 2022

Cui Wanyuan, Milner-Watts Charlotte, O'Sullivan Hazel, Lyons Hannah, Minchom Anna, Bhosle Jaishree, Davidson Michael, Yousaf Nadia, Scott Sophie, Faull Iris, Kushnir Marina, Nagy Rebecca, O'Brien Mary, Popat Sanjay

Abstract excerpt

BACKGROUND: Genomic sequencing is necessary for first-line advanced non-small cell lung cancer (aNSCLC) treatment decision-making. Tissue next generation sequencing (NGS) is standard but tissue quantity, quality, and time-to-results remains problematic. Here, we compare upfront cell-free-DNA (cfDNA) NGS clinical utility against routine tissue testing in patients with aNSCLC. METHODS: cfDNA-NGS was performed in...

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Identifiers

PMID: 35704974
DOI: 10.1016/j.ejca.2022.05.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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