Reduced Free Fatty Acid Receptor 4 Gene Expression is Associated With Extreme Obesity and Insulin Resistance in Children.

doi:10.1097/MPG.0000000000003360

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Article

Reduced Free Fatty Acid Receptor 4 Gene Expression is Associated With Extreme Obesity and Insulin Resistance in Children.

Journal of pediatric gastroenterology and nutrition - 1 Apr 2022

Codoñer-Alejos Alan, Carrasco-Luna Joaquín, Carrasco-García Álvaro, Codoñer-Franch Pilar

Abstract excerpt

OBJECTIVES: Free fatty acid receptor 4 (FFAR4) is a G-protein-coupled membrane receptor highly expressed in macrophages that triggers anti-inflammatory effects and promotes insulin sensitization. We have previously found significant associations between the FFAR4 rs11187533 single nucleotide polymorphism (SNP) and various obesity comorbidity parameters. We aimed to verify the FFAR4 expression levels in children...

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Identifiers

PMID: 35703949
DOI: 10.1097/MPG.0000000000003360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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