Article
Novel HLA associations with outcomes of Mycobacterium tuberculosis exposure and sarcoidosis in individuals of African ancestry using nearest-neighbor feature selection.
Genetic epidemiology - 1 Oct 2022
Dawkins Bryan A, Garman Lori, Cejda Nicholas, Pezant Nathan, Rasmussen Astrid, Rybicki Benjamin A, Levin Albert M, Benchek Penelope, Seshadri Chetan, Mayanja-Kizza Harriet, Iannuzzi Michael C, Stein Catherine M, Montgomery Courtney G
Abstract excerpt
Tuberculosis and sarcoidosis are inflammatory diseases characterized by granulomas that may occur in any organ but are often found in the lung. The panoply of classical human leukocyte antigen (HLA) alleles associated with occurrence and/or severity of both diseases varies considerably across studies. This heterogeneity of results, due to variation in factors like ancestry and disease subphenotype, as well as the...
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