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Mutation of PA4292 in Pseudomonas aeruginosa Increases β-Lactam Resistance through Upregulating Pyocyanin Production.

Antimicrobial agents and chemotherapy - 19 Jul 2022

Zhao Xinrui, Jin Yongxin, Bai Fang, Cheng Zhihui, Wu Weihui, Pan Xiaolei

Abstract excerpt

Metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa is increasingly reported worldwide and usually causes infections with high mortality rates. Aztreonam/avibactam is a β-lactam/β-lactamase inhibitor (BLBLI) combination that is under clinical trials. The advantage of aztreonam/avibactam over the currently used BLBLIs lies in its effectiveness against MBL-producing pathogens, making it one of the few drugs...

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Identifiers

PMID: 35695577
DOI: 10.1128/aac.00421-22
PMCID: PMC9295561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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