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Article

Structural basis of resistance to herbicides that target acetohydroxyacid synthase.

Nature communications - 11 Jun 2022

Lonhienne Thierry, Cheng Yan, Garcia Mario D, Hu Shu Hong, Low Yu Shang, Schenk Gerhard, Williams Craig M, Guddat Luke W

Abstract excerpt

Acetohydroxyacid synthase (AHAS) is the target for more than 50 commercial herbicides; first applied to crops in the 1980s. Since then, 197 site-of-action resistance isolates have been identified in weeds, with mutations at P197 and W574 the most prevalent. Consequently, AHAS is at risk of not being a useful target for crop protection. To develop new herbicides, a functional understanding to explain the effect...

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Identifiers

PMID: 35690625
DOI: 10.1038/s41467-022-31023-x
PMCID: PMC9188596

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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