Article
Computational design of novel inhibitors to overcome weed resistance associated with acetohydroxyacid synthase (AHAS) P197L mutant.
Pest management science - 1 Jul 2017
Qu Ren-Yu, Yang Jing-Fang, Liu Yu-Chao, Chen Qiong, Hao Ge-Fei, Niu Cong-Wei, Xi Zhen, Yang Guang-Fu
Abstract excerpt
BACKGOUND: Acetohydroxyacid synthase (AHAS; EC 2.2.1.6) is the first common enzyme in the biosynthetic pathway leading to the branched-chain amino acids in plants and a wide range of microorganisms. With the long-term and wide application of AHAS inhibitors, weed resistance is becoming a global problem, which leads to an urgent demand for novel inhibitors to antagonize both wild-type and resistant AHAS. RESULTS:...
Topics
- Acetolactate Synthase
- Brassicaceae
- Computational Biology
- Drug Design
- Enzyme Inhibitors
- Herbicide Resistance
- Herbicides
- Mutation
- Structure-Activity Relationship
- Weed Control