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Article

Effects of Short-term Fasting on Ghrelin/GH/IGF-1 Axis in Healthy Humans: The Role of Ghrelin in the Thrifty Phenotype.

The Journal of clinical endocrinology and metabolism - 18 Aug 2022

Hollstein Tim, Basolo Alessio, Unlu Yigit, Ando Takafumi, Walter Mary, Krakoff Jonathan, Piaggi Paolo

Abstract excerpt

CONTEXT: A greater decrease in 24-hour energy expenditure (24hEE) during short-term fasting is indicative of a thrifty phenotype. OBJECTIVE: As ghrelin and the growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis are implicated in the regulation of energy intake and metabolism, we investigated whether ghrelin, GH, and IGF-1 concentrations mediate the fasting-induced decrease in 24hEE that characterizes...

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Identifiers

PMID: 35678263
DOI: 10.1210/clinem/dgac353
PMCID: PMC9387714

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