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Article

Recharacterizing the Metabolic State of Energy Balance in Thrifty and Spendthrift Phenotypes.

The Journal of clinical endocrinology and metabolism - 1 May 2020

Hollstein Tim, Basolo Alessio, Ando Takafumi, Votruba Susanne B, Walter Mary, Krakoff Jonathan, Piaggi Paolo

Abstract excerpt

PURPOSE: The human thrifty phenotype hypothesis presupposes that lower 24-hour (24h) energy expenditure (24EE) during famine preserves body mass and promotes survival. The prevailing view defines thrifty individuals as having a lower 24EE during fasting. However, it is also plausible that the greater decline in 24EE during fasting in thrifty individuals is due to higher 24EE during energy balance conditions...

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Source

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Identifiers

PMID: 32118268
DOI: 10.1210/clinem/dgaa098
PMCID: PMC7341172

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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