Article
Reduced brown adipose tissue activity during cold exposure is a metabolic feature of the human thrifty phenotype.
Metabolism: clinical and experimental - 1 Apr 2021
Hollstein Tim, Vinales Karyne, Chen Kong Y, Cypess Aaron M, Basolo Alessio, Schlögl Mathias, Krakoff Jonathan, Piaggi Paolo
Abstract excerpt
BACKGROUND: We recently demonstrated that thrifty subjects, characterized by a greater decrease in 24 h energy expenditure (24hEE) during short-term fasting, have less capacity for cold-induced thermogenesis (CIT) during 24 h of mild cold exposure. OBJECTIVE: As cold-induced brown adipose tissue activation (CIBA) is a determinant of CIT, we sought to investigate whether thrifty individuals also have reduced CIBA....
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