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Unfolding and aggregation of oxidized metal-deficient superoxide dismutase and isoflavone inhibition based on ion mobility mass spectrometry and ThT fluorescence assay.

Archives of biochemistry and biophysics - 30 Sept 2022

Bian Xinyu, Zhuang Xiaoyu, Zheng Zhong, Liu Shu, Liu Zhiqiang, Song Fengrui

Abstract excerpt

Structurally abnormal Cu, Zn-superoxide dismutase (SOD1) is considered one of the causes of amyotrophic lateral sclerosis. The misfolding and neurotoxic aggregation of SOD1 can be induced by mutations, metal deficiency, and post-translational modification. Here, we revealed the risk of oxidation damage on zinc-deficient SOD1 by native mass spectrometry coupled with ion mobility. The copper ions were found to be...

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PMID: 35667444
DOI: 10.1016/j.abb.2022.109306

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