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Article

TFE-induced local unfolding and fibrillation of SOD1: bridging the experiment and simulation studies.

The Biochemical journal - 18 May 2018

Kumar Vijay, Prakash Amresh, Pandey Preeti, Lynn Andrew M, Hassan Md Imtaiyaz

Abstract excerpt

Misfolding and aggregation of Cu, Zn Superoxide dismutase (SOD1) is involved in the neurodegenerative disease, amyotrophic lateral sclerosis. Many studies have shown that metal-depleted, monomeric form of SOD1 displays substantial local unfolding dynamics and is the precursor for aggregation. Here, we have studied the structure and dynamics of different apo monomeric SOD1 variants associated with unfolding and...

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Source

Identifiers

PMID: 29686043
DOI: 10.1042/BCJ20180085

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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