Article
In silico identification of the rare-coding pathogenic mutations and structural modeling of human NNAT gene associated with anorexia nervosa.
Eating and weight disorders : EWD - 1 Oct 2022
Azmi Muhammad Bilal, Naeem Unaiza, Saleem Arisha, Jawed Areesha, Usman Haroon, Qureshi Shamim Akhtar, Azim M Kamran
Abstract excerpt
PURPOSE: Increased susceptibility towards anorexia nervosa (AN) was reported with reduced levels of neuronatin (NNAT) gene. We sought to investigate the most pathogenic rare-coding missense mutations, non-synonymous single-nucleotide polymorphisms (nsSNPs) of NNAT and their potential damaging impact on protein function through transcript level sequence and structure based in silico approaches. METHODS: Gene...
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