Article
Role of energy sensor TlpD of Helicobacter pylori in gerbil colonization and genome analyses after adaptation in the gerbil.
Infection and immunity - 1 Oct 2013
Behrens Wiebke, Schweinitzer Tobias, Bal Joena, Dorsch Martina, Bleich André, Kops Friederike, Brenneke Birgit, Didelot Xavier, Suerbaum Sebastian, Josenhans Christine
Abstract excerpt
Helicobacter pylori maintains colonization in its human host using a limited set of taxis sensors. TlpD is a proposed energy taxis sensor of H. pylori and dominant under environmental conditions of low bacterial energy yield. We studied the impact of H. pylori TlpD on colonization in vivo using a gerbil infection model which closely mimics the gastric physiology of humans. A gerbil-adapted H. pylori strain, HP87...
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