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Significance of prostate/pancreatic/skin cancer family history for detecting BRCA2 pathogenic variant careers among patients with breast cancer.

Breast cancer (Tokyo, Japan) - 1 Sept 2022

Minoura Yuko, Takahashi Masato, Maeda Hideki, Kuwahara Sayuri, Tachikawa Hanae, Yamamoto Mitsugu, Tomioka Nobumoto, Watanabe Kenichi, Sakurai Akihiro

Abstract excerpt

BACKGROUND: When considering BRCA1/2 genetic testing for diagnosis of hereditary breast and ovarian cancer (HBOC), family history (FH) of breast and ovarian cancer is commonly considered. However, FH of other HBOC-related cancers, such as prostate, pancreatic, and skin cancer (malignant melanoma), is often overlooked. METHODS: Among 945 patients who received genetic testing of BRCA1/2 at our hospital between...

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PMID: 35641852
DOI: 10.1007/s12282-022-01360-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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