Article
Proteomic analysis of the IPF mesenchymal progenitor cell nuclear proteome identifies abnormalities in key nodal proteins that underlie their fibrogenic phenotype.
Proteomics - 1 Jul 2022
Yang Libang, Gilbertsen Adam, Smith Karen, Xia Hong, Higgins LeeAnn, Guerrero Candace, Henke Craig A
Abstract excerpt
IPF is a progressive fibrotic lung disease whose pathogenesis remains incompletely understood. We have previously discovered pathologic mesenchymal progenitor cells (MPCs) in the lungs of IPF patients. IPF MPCs display a distinct transcriptome and create sustained interstitial fibrosis in immune deficient mice. However, the precise pathologic alterations responsible for this fibrotic phenotype remain to be...
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