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Comparison of Varicella-Zoster Virus RNA Sequences in Human Neurons and Fibroblasts

6 Mar 2014

Abstract excerpt

Varicella-zoster virus (VZV) infection causes varicella, after which the virus becomes latent in ganglionic neurons. In tissue culture, VZV-infected human neurons remain viable at 2 weeks, whereas fibroblasts develop cytopathology. Next-generation RNA sequencing was used to compare VZV transcriptomes in neurons and fibroblasts and identified only 12 differentially transcribed genes of the 70 annotated VZV open...

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Herpesvirus Infections and Treatments
Toxin Mechanisms and Immunotoxins
Vector-borne infectious diseases

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24600007
DOI: 10.1128/jvi.00476-14

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