Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Potential opposite roles of the extracellular signal-regulated kinase (ERK) pathway in autism spectrum and bipolar disorders.

Neuroscience and biobehavioral reviews - 1 Nov 2012

Kalkman Hans O

Abstract excerpt

Signal transduction from the synapse to the nucleus subsequently involves transient increases in synaptic Ca2+, activation of CaM kinases, activation of the GTPase Ras, activation of the ERK mitogen-activated protein kinase pathway, and finally GSK3 inhibition and CREB-activation. Genetic studies in autism have identified mutations and copy number variations in a number of genes involved in this synapse to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autistic Disorder
Share to Bipolar Disorder
Share to Circadian Rhythm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

Share to Mutation

Share to Signal Transduction

Source

Identifiers

PMID: 22884480
DOI: 10.1016/j.neubiorev.2012.07.008

Genes

MAPK3
SYNGAP1
YWHAE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Potential opposite roles of the extracellular signal-regulated kinase (ERK) pathway in autism spectrum and bipolar disorders.PMID 22884480Read ↗

A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors.Semantic proximity Read ↗

Scribble controls social behaviors through the regulation of the ERK/Mnk1 pathwaySemantic proximity Read ↗

MAP'ing CNS development and cognition: an ERKsome process.Semantic proximity Read ↗

The role of calcium-dependent gene expression in autism spectrum disorders: lessons from MeCP2, Ube3a and beyond.Semantic proximity Read ↗

Autism associated mutations in β2 subunit of voltage-gated calcium channels constitutively activate gene expression.Semantic proximity Read ↗

Scribble Controls Social Motivation Behavior through the Regulation of the ERK/Mnk1 Pathway.Semantic proximity Read ↗

Voltage-gated Calcium Channels and Autism Spectrum Disorders.Semantic proximity Read ↗

Elevated basal transcription can underlie timothy channel association with autism related disorders.Semantic proximity Read ↗

Lymphocytic Extracellular Signal–Regulated Kinase Dysregulation in Autism Spectrum DisorderSemantic proximity Read ↗

Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression.Semantic proximity Read ↗

Calcium signalling and psychiatric disease: bipolar disorder and schizophreniaSemantic proximity Read ↗

Increased expression of BDNF mRNA in the frontal cortex of autistic patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.